Wednesday, 5 June 2019

Amoeba-biology-notes


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Classification
                Phylum   Protozoa - Simple, Acellular animals. (According to DOBELL).

                Subphylum   Sarcomastigophora (Plasmodroma) - Locomotive organs are flagella or                        pseudopodia.

                Class – Rhizopoda (or sarcodina) - Locomotive organs are pseudopodia.
                Order   Lobosa (or Amoebina) - Pseudopodia are with rounded ends called lobopodia.
                Genus    Amoeba.
                Species – Proteus - Body is variable in shape.

                          DISCOVERY AND HISTORY

                R.V. Rossenhoff has discovered Amoeba. Termed it as "Little Proteus" on the name of a                    God of Yunan who was able to change his shape.
                Saint Vincent Named "Amiba" which was further changed to "Amoeba".
                Heirsch Field has done detailed study of Amoeba.

               - Most of the species of Amoeba are found in fresh water and feeds on Algae and Bacteria.
               - It is present in dirty water with mud.
               - Culture of Amoeba can be done by Hay infusion process.

                Dry and clean leaves, grass, wheat grains are boiled in distilled water for 15 minutes.
                                After filtration allow to stand for 2-3 days. Bacterial growth will take place.
                                Half rotten leaves from pond are washed and put into filtrate. Within a week,                                      filtrate will have good numbers of Amoeba.

                                - Two species of Amoeba are also found in sea water or marine water.
                                - Amoeba verucosa
                                - Amoeba striata
                                - Amoeba radiosa - Found in tropical areas. This is the most common species                                        found in India.
                                - Amoeba proteus - Present in Temperate atmosphere. The maximum study is                                       done of this species because its structure is like a simple cell and the size is also                                    sufficient.
                                -Amoeba pelomyxa – (Chaos - chaos) – Giant Amoeba. This is the biggest                                             Amoeba, its structure is uncommon because it is exceptionally multinucleated.

                                              SHAPE AND SIZE

 Amoeba is a micro organism. Size varies from .2 mm to .6 mm . It is colourless and transparent. Shape is variable because pseudopodia are continously forming and disappearing and also because pellicle is absent.

 Exceptionally due to presence of pellicle in Amoeba verucosa and striata, pseudopodia are not formed and their shape is fixed.

 Body of Amoeba is differentiated into Protoplasmic membrane, Cytoplasm and Nucleus.
 Protoplasmic membrane   This is the outermost coating. It is 0.2m to 2m in thickness. It is a thin, soft, selectively permeable unit membrane which is capable of regeneration.

Electron microscope shows that hair like extensions are present on whole of the membrane. These are called microvilli. They are mucoprotein in nature. These micorvilli helps Amoeba in adhesion with ground.

                                                       CYTOPLASM

                It is divided into two parts
                Outer    – Ectoplasm or Ectosarc
                Inner     – Endoplasm or Endosarc

1.   Ectoplasm – It is transparent and present in form of a thin layer. It is devoid of granules and structures. It is differentiated into two areas.
 Outer part is made of a watery fluid which is called "Hyaline layer". This layer is thick in pseudopodia and called as "Hyaline cap". it gives strength to pseudopodia. Internal part is made of plasmagel.

-  The ectoplasm of Amoeba proteus contains various perpendicular projections. These are called as "longitudinal ridges". These ridges causes friction and helps Amoeba to adhere with the ground.

2.  Endoplasm – It is semi transparent  and granular. All the structures of Amoeba are present in endoplasm.
   According to "Mast", Endoplasm is divided into two parts. Internal – Plama sol, Peripheral – Plasma gel.
  But Electron microscope does not show this type of division. So whole of the endoplasm is considered as Sol in nature as per the modern theory.

                                                            NUCLEUS

   Normally Amoeba is uninucleated but exceptionally Amoeba diploidia has two nuclei. While Amoeba pelomyxa is multi nucleated.
                The nucleus of young or baby Amoeba is biconcave but biconvex in adult Amoeba.
                A network of protein fibers is present just inside the nuclear membrane. It is honey comb                    in  shape known as "Honey comb lattice". It maintains the shape of nucleus.
                Nucleus of Amoeba is massive in nature, it means that chromatin material is more and                         nucleoplasm is less in quantity. Chromatin material is present in spherical granules known                   as "Chromidia". These are 500-600 in number Every chromidia is made up of one or two                     genes.

                                                 CELL ORGANELLS

  CONTRACTILE VACUOLE (C.V.) – It appears like a bubble of clear watery fluid enclosed within delicate condensation membrane. Only one in number. It is formed by union of many small vacuoles. C.V. is present in Endoplasm. Its position is not fixed but usually it is present between nucleus and rear part of Amoeba (Uroid).

Function of CV is osmoregulation. The liquid medium around Amoeba is Hypotonic so water enters in from outside continousely. This extra incoming water is thrown out by C.V.
 Functionally C.V. is equivalent to kidney or nephron or uriniferous tubules of higher animals.     
 Numerous long tubules are related to C.V. These are called Feeding canals or Radiating canals. These canals collect water from cytoplasm and drain into C.V.

                Increase in size of C.V. is due to filling of water called Diastole.
                When C.V. becomes sufficiently large it bursts near plasmalemma and water is thrown out.                  This process is called systole.
                Many small vacuoles combines to form a C.V. The maximum energy is used in this process                  so many Mitochondria surround the C.V.

                - The functional ability of C.V. increases when Amoeba is put in distilled water.
                - When Amoeba is transffered from fresh water to marine, C.V. disappears.
                - When marine amoeba is transffered to distilled water a new C.V. is formed.

                Food Vacuole – Many food vacuoles are present in endoplasm Every time when food is                        ingested, a new food vacuole is formed and full digestion occurs in this vacuole.
                Functionally it is closely related to alimentary canal of higher animals.

                Water Vacuoles - These are small, non contractile vacuoles filled with water present in                           endoplasm. Its function is unknown.

                Biurets And Triurets - Many bipyramidal and tripyramidal crystals are present in                                  endoplasm of Amoeba. These crystals are made up of excretory product carbonyl diurea.                      Probably these crystals are excreted during reproduction.

               - Stored food of Amoeba is Glycogen and oil drops.
               - Every cell organelle like ER, Mitochondria, Golgi comples, Lysosomes, Ribosome etc are                  present in cytoplasm except centriole.

               - Endoplasmic reticulum in Amoeba does not contain cisternae.
                 Locomotion in Amoeba
               - Amoeba is a polypodial animal but the locomotion is monopodial. Amoeba uses single                       pseudopodia in locomotion. This movement is called amoboid movement.
               - A pseudopodium can form at any point on body surface. It first formed homogenous fluid                   called hyaline cap. When this touches substratum, granular endoplasm rush into it                                resulting  elongation and become distinct pseudopodia.
              -  Speed is .02 – .03 mm / min.

Locomotion in Amoeba is completed in three stages -
         1. Adhesion with base - In this process micrvoilli, longitudnal ridges and ions present in water                  like Ca++, Mg++, K+ etc. are helpful.

         2. Interconversion of sol and Gel - This is essential for pseudopodia formation.

         3. Contraction in body - Amoeba moves forward by this contraction.

Theories Related with Locomotion -
         1.  Rolling Movement theory   - This theory was proposed by "Jenings".
                This type of rolling movement was observed on Amoeba verucosa. This theory is possible for only two species -               
                                Amoeba verucosa
                                Amoeba striata
                                Amoeba roll like a football during locomotion.
          2.Contraction theory   This theory is given by Heitzman & Schultze.
             - According to this theory a pseudopodium is formed due to contraction. Contraction occurs                in posterior portion of Amoeba while pseudopodia forms in front part or in the direction of                  locomotion.
                This theory is not valid because only contraction is not responsible for pseudopodia                               formation.

             3. Walking movement theory   This theory was given by Dellinger. This theory says that pseudopodia forms in the front part. These pseudopodia serves as feet for Amoeba. With the help of these pseudopodia Amoeba lifts up from the ground and feet like pseudopodia causes locomotion. Pseudopodia disappeares in the back part and are appear as wrinkles. These wrinkles are called Uroids. Due to these uroids, Amoeba shows polarity.
 This theory is not valid because at the time of locomotion Amoeba is in contact with surface.

             4. Surface tension theory   Proposed by Berthold. Butschli and Rhumbler supported this theory. according to this theory pseudopodia are formed due to difference in surface tension of body of Amoeba and ground.

             5. Fountain Zone theory   Proposed by Allen.
                According to this, sol is present in periphery while gel is inside. This central gel moves like a fountain in the direction of locomotion. This fountain applies pressure over ectoplasm and thus pseudopodia is formed.
  But this theory  was discarded because in Amoeba sol is always inside while gel is always outside.

6.Sol-Gel theory  is Based on change in viscosity theory. Proposed by Hyman. Its detail study was done by  Pantin and Mast
                This theory suggest that pseudopodia are formed due to interconversion of sol and gel.
                In locomotion sol flows in the direction of locomotion and breaks the gel barrier. This sol                   strikes with the ectoplasm. After striking it moves on either side and converts into gel.
                In locomotion the gelation process occurs in front while solation (gel - sol) occur in rear.

- Sol continousley strikes with ectoplasm therefore ectoplasm grows in size and spreads 
outward hence a small hyaline cap as a small bulge representing begining of pseudopodia. This process helps in pseudopodia formation.


-    Pseudopodia is a tube like structure of ectoplasm in which endoplasm is filled. The wall of pseudopodia is made up of gel while sol in inside.

                Drawbacks
                1.            This theory do not explain the sol-gel interconversion.
                2.            It does not mention about the force by which sol moves forward.

                Some theories in favour of sol-gel theory :

(i)  Molecular folding unfolding theory   Proposed by Goldacre and Lorch. It explains the sol-gel interconversion. This is a Biochemical and biophysical process. The sol form of protoplasm is due to tertiory structure (folded state) of protein.

  While the gel form is due to secondary structure (Unfolded state) of Protein.


(ii)  Contraction Hydraulic theory 
                Earliar given by Schultze and detailed explanation was give by Rinaldi. It explains how sol moves in the direction of locomotion. According to this, actin and myosin type of proteins are present in rear portion of Amoeba. These proteins produce hydraulic pressure by contraction. This pressure is maximum in front, minimum in middle and medium in rear.
                According to "Huxley" the proteins participating in solution and gelation are similar to actin and myosin of muscles fibres.

Nutrition
                Nutrition in Amoeba is Holozoic or Zootropic which involve ingestion of food and then digestion and absorption.
                Amoeba is omnivorous. It likes to take bacteria, algae, cilliated and flagellated Protozoans. There is no pore for ingestion and excretion of digested food. Any part of plasmalemma can ingest food and excrete digested food.

                Some protozoans like Paramoecium contain pore. These are called Cytostome and Cytoproct. (or cytopyge)

Methods of food ingestion (Studied by Rhumbler)

1. Import - Amoeba do not effort in this method. Any moving food when strikes with amoeba it is embeded into the cytoplasm (Passive food ingestion).

2.  Invagination - By this process small and non-motile food is ingested. This type of food comes in contact with plasmalemma which invaginates and food is ingested due to invagination of plasmalemma in the form of a food vacuole.

3. Circumfluence - This process is used to ingest large and nonmotile or less active food e.g. Filaments of algae.
 In this process cytoplasm of amoeba flows around the food and encircle it.Plasmalemma invaginates and forms a food cup which further converts to a big food vacuole.

4.   Circumvallation - By this process amoeba ingests active, motile food. Food is surrounded by several small pseudopodia. Later these pseudopodia unites and forms a food cup. Finally prey is embedded in the endoplasm. Amoeba can also ingest colloids from surrounding by pinacytosis and form pinocytic vesicle.

 Digestion
                Digestion takes place in food vacuoles by means of lysosomal enzymes release from Lysosome which get fuse and merge with food vacuoles. These enzyme work effectively only when medium in food vacuole is alkaline.

- Just like higher animals digestion is completed first acidic and then alkaline phase.

- First HCl produced from fluid of vacuole made food loose, soft and semitransparent. And 
simultaneously vacuole loses water and become smaller. Then Lysosome release their enzyme into vacuole which made vacuole alkaline.

- Proteolytic enzymes like trypsin, peptidases and lipolytic enzyme lipase are found but carbohydrate-digesting enzyme or amylolytic enzyme is very less.

- Thus proteins hydrolysed to amino acids and fats to fatty acid and glycerol. Due to increase osmotic concentration water is reabsorbed.

-  Food vacuole remain in endoplasm for about 30mts for completing digestion. End product of digestion diffuse out from the vacuole to all part of body.

- Excess amino acid changed to sugar and store as glycogen as reserve food.

- Food vacuole with undigested food is thrown out.

 Respiration And Excretion

                Both these functions are completed by plasmalemma through diffusion.
                Amoeba is an obligate aerobe. It depends only on aerobic respiration. So when Amoeba is                   put under O2 less water it dies.

- In view of excretion Amoeba is Ammonotelic.

 Reproduction

1.Binary fission - Simplest type of reproduction. It occurs in desirable condition. In this process divison is primitive type of mitosis called as Cryptomitosis.

                Phases of this division are as under -

                i. Prophase - Contractions in C.V. Stops. Numerous small pseudopodia arises on whole of                    the surface of Amoeba. Amoeba is covered by hyaline caps. Therefore entry of water                         becomes slow.
                Nucleolous and Honey comb lattice in nucleus disappears but nuclear membrane persists.
                Nucleolous and Honey comb lattice in nucleus disappears but nuclear membrane persists.
                Chromidia become condensed and clear. Spindle formation starts in nucleus. These are                        called intranuclear spindles.

                ii. Metaphase - Chromidia forms metaphase plate by adjusting themselves in the middle of                  nuclues.
                Spindles are arranged on different poles of nucleus. These are called multipolar spindle.                      This is an unique character of binary fission in Amoeba.

                iii. Anaphase - Pseudopodia becomes less in number but size increases. Multipolar spindles                   are converted into bipolar spindles (spindle fibers). Now chromidia       separate so that                       chromidia approaches the two poles of nucleus. Simultaneously nucleus becomes larges                       and show constriction in middle.
                At the end of Anaphase nucleus is dumble shaped.

                iv. Telophase - At this stage nucleus and cytoplasm divides. It results in formation of two                   daughter Amoeba. Size of daughter Amoeba is greater than the half of the size of parent                       Amoeba.
                Old C.V. remains in any one of the daughter Amoeba. While the other forms a new one.                      Binary fission is completed in 30 mt. It maybe repeated after 48 hrs.

2.  Sporulation -

                i. Sometimes Amoeba reproduces by sporulation in unfavourable conditions.
                ii. When excessive energy is spent continously, binary fission ability decreases. To                               reproduce further  it does sporulation. Spore is the resting stage of Amoeba hence it saves                   energy.

-  In sporulation Amoeba retracts its pseudopodia and becomes sphere shaped.  

- Nuclear membrane disappears and chromidia disperse in the sets of 2 or 3 chromidia. Every set of chromidia is surrounded by a newly formed nuclear membrane.

-  After that cytoplasm divides and breaks in 200 pieces and surrounds each small nucelus. Every piece now secretes a hard and thick coat around itself. This structure is called spore.

- About 200 spores are formed by this process. Coat of spore is made up of chitin.

- Now plasmalemma of parent Amoeba dissolves and spores are spread out.

- When favourable conditions arrive, spore germinates. They absorb water and swollow. Thick coat splits and a young Amoeba comes out.

-  In this young stage endomitosis occurs in nucleus so that chromidia increases in number up to 500-600. Nucleus formed by endo mitosis is called Restitution or polyenergid nucleus.

- Spore also helps in dispersion of Amoeba.


3.Encystment and Multiple fission    This process is used under unfavourable conditions, like lack of O2 , lack of food and at high temp. In this case Amoeba secretes a three layered thick coat around itself called cyst. Coat of cyst is made up of chitin like that of spore. It is impermeable to water and permeable to O2 and CO2.
                Inside cyst amitosis occurs several times so that 500 small Amoeba are formed. These are called pseudopodiospores or Swarm spores.

- On return of favourable conditions cyst spits and Amoeba get freed in water.

-  According to modern scientists, multiple fission is very rare.It is not a process of reproduction it is a process of perennation.

- Amoeba is least active inside cyst. This phenomenon is called  "Suspended Animation". This is also a process of dispersion but its efficiency is more than spore.
Rejuvenation - This is also called non-functional conjugation. In this process two old amoeba come close to each other and adhere themselves. After a while they get separated.  Now these both amoeba are more active than before. (No Exchange of matter.)

 Regeneration - Studied by Bruno & Hoger. Amoeba has tremendous power of regeneration.

- Any part of  Amoeba which contain at least one chromidia may regenerate but piece without nuclears can not regenerate.

 Immortality in Amoeba   Studied by Hertman
                Amoeba is immortal because its natural death do not occour as a parent Amoeba is converted completely into two daughter Amoeba by binary fission.
                Immortality can also be explained on the basis of "Germplasm theory of weisman". According to this theory Amoeba is not differentiated into somatoplasm and Germplasm.

                This type of differentiation is present in multicellular animals.
               Irritability
-Amoeba has protoplasmic grade of irritability.

- Maximum taxis movement of Amoeba are negative, these are called phobotaxis.

- Some positive taxis are also present these are called philotaxis.

 Types of irritability :

1.  Thigmotaxis - Normally phobotaxis, but in response to food it is always philotaxis.

2.Phototaxis - Amoeba likes dim light. So phobotaxis is seen in response to bright light & darkness.

3.Thermotaxis - Optimum temp is 20-250C. When Amoeba is kept suddenly under high temperature it dies but when rise in temp is gradual it forms cyst.

4.Chemotaxis – Amoeba shows phobotaxis when kept under water in which those chemicals are present that are not present normally in water.

5. Galvanotaxis - When low current is passed Amoeba moves toward cathode but in high  current it dies.

6.Rheotaxis - Amoeba moves with the flow of water.

7. Geotaxis-  Philotaxis because Amoeba like to live in bottom. These animals are called benthos or benthic.


ENTAMOEBA HISTOLYTICA

                Entamoeba histolytica is discovered by Lamble. Losch discovered its pathogenic nature.
                Entamoeba Histolytica is a parasitic Amoeba and it causes "Amoebic dysentry". A patient with this disease has acidic stools. Stool also contain mucous, blood and cyst of Entamoeba. So this disease is diagnosed by stool test.
                Entamoeba Histolytica is a parasite of large intestine(colon) of man. It secretes histolytic enzymes which causes harm to wall of intestine. Entamoeba destroys the mucosa and submucosa of colon and enters in its wall and injest tissue, RBC etc, and form flask shaped ulcer from which mucous and blood comes out and pass into stools of the host. It may also approach in other organs of body like liver, lungs, kidney, brain etc. through blood circulation.
                Basically structure of Entamoeba is similar to Amoeba, but C.V. is absent in Entamoeba.
                It's food vacuole contains R.B.C., W.B.C. and bacteria as these substance are used as food.
                Nucleus of Entamoeba is vesicular i.e. chromatin material is less and Nucleoplasm is more.
                Chromidia are arranged on periphery of nucleus. At the center of nucleus a false nucleolus or karyosome or Endosomes occurs. Endosome is surrounded by a small  clear shiny and transparent area which is called Halo. Nucleoplasmic striations connect Halo to chromidia.
                Entamoeba Histolytica is monopodial animal. In its rear portion plasmalemma is geletinous and sticky. It helps in sticking of food particles. Food is ingested by the process of invagination. This is the only process of taking food.
Two forms of Entamoeba are there :
                (i)            Trophozoites or Magna form.(20-30u)
                (ii)           Precyst or Minuta form.(12-15u)
                Trophozoites form is larger than Minuta form. Trophozoites is the adult stage of Entamoeba. This stage of Entamoeba is motile, actively feeding and pathogenic.


                Life Cycle - Few daughter Amoeba which are formed by the asexual multiplication of Trophozoites grow in to normal adult whereas few dauthter Amoeba remain small and escape from the lumen of the colon known as minuta form or precystic Amoeba.
Cytoplasm of these minuta contain only one or two granules of glycogen, but contains a dense body called as "Chromatoid body". Possibly it is made up of Ribo nucleoproteins which further disappear.
                Minuta secretes a thin but strong coat around itself called cyst. Nucleus of cyst undergo two mitosis and a tetra nucleated cyst is formed. It is carried out from the body by stools of the patient.
                This tetra nucleated cyst is the infective stage of Entamoeba for human.
                Cyst enters in human by impure water and food. Houseflies also carry these cyst to food. When these cysts reach to colon, their hard coat is damaged. This process is called hatching or excystment.  Now Tetra nucleated stage comes out. This is called Metacyst. Metacyst undergo binary fission and eight Entamoeba are formed.
                All these Entamoeba enters the wall of colon and after growth converted into Trophozoite. Some medicines used in prevention of diseases caused by Entamoeba Histolytica are Emetine, Diodoquin, Dependal, Carborsone metrogyl, Magma, Amicline.

ENTAMOEBA GINGIVALIS
                Size of trophozoite - 12-20u.
                It is present in Tartar which is deposited in between teeth. Approximately 70% humans are infected by this. Some times it also infect gums. It has 2-3 pseudopodia and contain several food vacuole.
                Entamoeba gingivalis is a human parasite but it is not pathogenic.It helps some pathogenic protozoa in infection e.g. Trichomonas tinax, Trichomonas buccalis both of these causes pyorrhoea.
-              Entamoeba gingivalis does not form cyst.
-              It spreads through mouth to mouth by kiss. It trophozoites feeds on bacteria, debris WBC.
-              Prevention may be done by using sensoform mouth wash
-              Treatment can be done by Garamycin.
ENTAMOEBA COLI. (E. Coli) - (Trophozoite - 20-40 m )
-              This species is found in human colon.
-              It shows commenselism Host is neither in gain nor in loss.
-              It feeds on non digestive food & Bacteria and do not invade colon wall.
-              Eight-nuclei are found in the mature cyst.
 Special Point
1.            Pelomyxa is the biggest Amoeba.
2.            Amoeba proteus is a free living and solitary animal
3.            Amoeba is omnivorous.
4.            Amoeba is polypodial where as Entamoeba is Monoipodial
5.            Amoeba shows polarity as uroids are present on back.
6.            Chromatin material of Amoeba is granular and called chromidia.
7.            Gaseous exchange in Amoeba is done through body surface.
8.            Excretion of Ammonia is also done through body surface.
9.            The universal theory for locomotion in Amoeba is sol-gel theory
10.          Mechanism of binary fission in Amoeba is cryptomitosis.
11.          General method of reproduction in Amoeba is binary fission.

                                                 Problems for practice


1.     What is absent in Amoeba-
             (1) Mitochondria                    (2) Ribosome
             (3) Golgibody                        (4) Centriole

2.     Attachment of Amoeba to substratun is facilitated by -
             (1) Rough surface                 
              (2) Secreting chemicals
             (3) traces of inorganic ions inwater (Ca++, Mg+2, K+)
             (4) low surface tension

3.     The excretion in Entamoeba histolytica takes place by -
             (1) Contractile vacuole
             (2) General body surface
             (3) Food vacuoles
             (4) none of the above

4.   Amoebic dysentry or amoebiasis is caused by -
             (1) Entamoeba histolytica
             (2) Amoeba proteus
             (3) Entamoeba coli
             (4) Entamoeba indica

5.      Excretory product in Amoeba is -
             (1) Ammonia (NH3)               (2) Urea
             (3) Uric acid                           (4) none

6.     If an Amoeba is place in oxygen less atmosphere it -
             (1) Dies immediately
             (2) form pseudopodia          
             (3) Form cyst
             (4) rapidly multiplies

7.     If nucleus is removed from Amoeba-
             (1) Dies immediatedly
             (2) Remaince alive
             (3) froms pseudopodia
             (4) does not grow and dies ultimately
8.     Entamoeba histolytica differs from Amoeba proteus due to absence of     
             (1) Nucleus
             (2) Food vacuole     
             (3) contractile vacuole                                                           
             (4) all of the above
9.     In Amoeba, lobopodia are formed due to
             (1) Excess of ATP
             (2) Sol-gel interconversion
             (3) entry of more water in body
             (4) spontaneous
10.     If Amoeba is placed under unfavourable conditions
             (1) retracts pseudopodia      
             (2) forms pseudopodia
             (3) undergoes rapid division
             (4) remains alive
11.   How many Amoeba are formed from a single cyst of Entamoeba histolytica
             (1) 2
             (2) 4                                         
             (3) 8
             (4) 16
12.   Food is stored in which form in Entamoeba histolytica  
             (1) Glycogen                           (2) Fats
             (3) Protein                               (4) Starch
13.     Entamoeba gingivalis found in
             (1) Last end of tongue
             (2) In between gums and teeth
             (3) Inner surface  of  cheeks
             (4) Throat
14.            Amoeba exhibits tactic movement in response to
             (1) Touch                                 (2) Heat
             (3) light                                    (4) all of the above
15.            In Amoeba amount of water increases by
             (1) by endoosmosis
             (2) at the time of ingestion of food
             (3) by matabolism reactions
             (4) all of the above
16.            Entamoeba coli obtain nutrition from
             (1) Saliva
             (2) Mucous                             
             (3) Tissue layer
             (4) Undigested food in intestine
17.            If a marine Amoeba is transferred to fresh water
             (1) Die
             (2) No change                        
             (3) Form New contractile vacoule
             (4) It bursts
18.            Which substance is minimum in Amoeba body
             (1) Carbohydrates                 (2) Protein
             (3) Fats                                 (4) Nucleic Acid
19.            Naked Amoeba found in     
             (1) Fresh water                        (2) Marine water
             (3) Wet soil                              (4) All of the above
20.            During digestion changes in food vacuole of Amoeba occur in                                       
             (1) Only PH                             (2) Only size
             (3) PH and size                        (4) None
21.            The pseudopodia are formed in Amoeba
             (1) When it comes in contact with food particles
             (2) By sol-gel transformation
             (3) When body stricks with substration
             (4) When food is large
22.            In which class Amoeba is placed
             (1) Ciliata                                (2) Mastigophora
             (3) Sporozoa                           (4) Sarcodina
23.            By which method active food like Paramoecium ingested by Amoeba proteus-
             (1) Circumvallation               (2) Circumfluence
             (3) Invagination                     (4) Import
24.            Contractile vacuole found in
             (1) Amoeba proteus and Entamoeba
             (2) Plasmodium and Amoeba Proteus
             (3) Paramoecium and Amoeba Proteus
             (4) Euglena and Entamoeba
25.            Which type of pseudopodia are present in Amoeba Proteus                                            
             (1) Lobopodia                        (2) Exopodia
             (3) Filopodia                           (4) Reticullopodia
26.            Asexual reproduction in Amoeba
             (1) Binary fission                   (2) Multiple fission
             (3) Sporulation                       (4) all of the above
27.            In which type of medium occours in food vacuole of Amoeba                                       
             (1) First acidic and then alkaline
             (2) only alkaline
             (3) first alkaline and then acidic
             (4) only acidic
28.            By which method solid food is ingested in Amoeba
             (1) Phagocytosis                     (2) Pincocytosis
             (3) both                                    (4) none
29.            Which cell organelle is most abundant around food vacuole in Amoeba
             (1) Golgibody                          (2) Lysosome
             (3) Ribosomes                        (4) Mitochondria
30.            Circumfluence in Amoeba is a method of
             (1) Binary fission                   (2) locomotion method
             (3) Foot ingestion                   (4) Excretion
31.            Amoeba exhibits positive response to
             (1) Strong light
             (2) dim light
             (3) strong electric current     
             (4) strong chemical substances
32.            Besides locomotion pseudopodia of Amoeba help in
             (1) Reproduction                    (2) Ingestion
             (3) Respiration                       (4) Excretion
33.            Site of solation in Amoeba is
             (1) Anterior end where pseudopodia form degenerate     
             (2) Posterior end where pseudopodia degenerate
             (3) Places where C.V. disappear
             (4) Posterior end where pseudopodia form
34.            Main function of contractile vacuole in Amoeba
             (1) Excretion of excess of salts
             (2) Excretion
             (3) Temperature regulation
             (4) Osmoregulation
35.            In weak electric current Amoeba
             (1) Movement towards Cathode
             (2) Movement towards Anode
             (3) Dies
             (4) Encystment
36.            In which form Amoeba ingest food
             (1) Ingestion of whole animal
             (2) Fully digested food
             (3) Animal of class crustacea
             (4) none of the above
37.            A fresh water Amoeba respires by means of
             (1) Gills
             (2) Food Vacuole                  
             (3) Plasmalemma
             (4) Contractile vacuole
38.            In Amoeba nitrogenous wastes are expelled out through
             (1) Pseudopodia                     (2) Hyalinecap
             (3) Plasmalemma                   (4) Contractile vacuole
39.            The method of food intake in Amoeba is called
             (1) Saprophytic                      (2) Holozoic
             (3) Holophytic                       (4) Parasitic
40.            A full grown Amoeba undergoes binary fission, the total surface area of one
             daughter Amoeba soon after division is   
             (1) Equal to half parent Amoeba
             (2) Slightly less than half of parent Amoeba
             (3) Same as parent Amoeba
             (4) slightly more than half of parent Amoeba
41.            Amoeba reproduces during unfavourable conditions by-                                                 
             (1) Conjugation                      (2) Binary fission]
             (3) Encystment                      (4) All of them
42.            When the pond is going to dry Amoeba will
             (1) Show no change
             (2) Feeds quickly
             (3) Encysts
             (4) Divides by binary fission
43.            The conversion of plasmagel into plasmasol and vice versa in Amoeba was first studied by
             (1) Pantin                                 (2) Hymen
             (3) Mast                                   (4) Taylor
44.            Binary fission in Amoeba occurs
             (1) When environment is favourable                                   
           (2) Food is abundant
             (3) Temperature is suitable
             (4) Food abundant and temperature is suitable
45.            Contractile vacuole of Amoeba is analogous to vertebrate                                              
             (1) Uriniferous tubules          (2) Pulsating heart

             (3) Sweat glands                    (4) Rectum


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